Article
The use of Mendelian randomisation to identify causal cancer risk factors: promise and limitations.
The Journal of pathology - 1 Apr 2020
Gala Harvinder, Tomlinson Ian
Abstract excerpt
The use of observational analyses, such as classical epidemiological studies or randomised controlled trials (RCTs), to infer causality in cancer may be problematic due to both ethical reasons and technical issues, such as confounding variables and reverse causation. Mendelian randomisation (MR) is an epidemiological technique that uses genetic variants as proxies for exposures in an attempt to determine whether...
Topics
- Disease Susceptibility
- Genetic Variation
- Genotype
- Humans
- Mendelian Randomization Analysis
- Neoplasms
- Risk Factors
- United Kingdom