Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Phenotarget Approach for Identifying an Alkaloid Interacting with the Tuberculosis Protein Rv1466.

Marine drugs - 5 Mar 2020

Xie Yan, Feng Yunjiang, Di Capua Angela, Mak Tin, Buchko Garry W, Myler Peter J, Liu Miaomiao, Quinn Ronald J

Abstract excerpt

In recent years, there has been a revival of interest in phenotypic-based drug discovery (PDD) due to target-based drug discovery (TDD) falling below expectations. Both PDD and TDD have their unique advantages and should be used as complementary methods in drug discovery. The PhenoTarget approach combines the strengths of the PDD and TDD approaches. Phenotypic screening is conducted initially to detect cellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkaloids
Share to Antitubercular Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Delivery Systems

Share to Drug Discovery

Share to Drug Evaluation, Preclinical

Share to High-Throughput Screening Assays

Share to Plant Extracts

Share to Proteome

Source

Open in PubMed Open full text

Identifiers

PMID: 32150903
DOI: 10.3390/md18030149
PMCID: PMC7143284

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

A Phenotarget Approach for Identifying an Alkaloid Interacting with the Tuberculosis Protein Rv1466.PMID 32150903Read ↗

Discovery of a Natural Product That Binds to the Mycobacterium tuberculosis Protein Rv1466 Using Native Mass SpectrometrySemantic proximity Read ↗

Exploring optimal drug targets through subtractive proteomics analysis and pangenomic insights for tailored drug design in tuberculosisSemantic proximity Read ↗

Naturally occurring Dinactin targets cpsA of LytR-Cps2A-Psr family protein as well as kills Mycobacterium tuberculosis by disrupting proton motive forceSemantic proximity Read ↗

Chemo‐proteomics in antimalarial target identification and engagementSemantic proximity Read ↗

Proteome-wide Profiling of Isoniazid Targets in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Chemical Proteomics Identifies Nampt as the Target of CB30865, An Orphan Cytotoxic CompoundSemantic proximity Read ↗

Assessment of Mycobacterium tuberculosis pantothenate kinase vulnerability through target knockdown and mechanistically diverse inhibitors.Semantic proximity Read ↗

A High-Throughput Screen against Pantothenate Synthetase (PanC) Identifies 3-Biphenyl-4-Cyanopyrrole-2-Carboxylic Acids as a New Class of Inhibitor with Activity against Mycobacterium tuberculosisSemantic proximity Read ↗

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.Semantic proximity Read ↗

Pyrazinamide triggers degradation of its target aspartate decarboxylaseSemantic proximity Read ↗

Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.