Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to whole-slide images.

doi:10.1002/cam4.3107

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Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to whole-slide images.

Cancer medicine - 1 Jul 2020

Ono Akira, Terada Yukihiro, Kawata Takuya, Serizawa Masakuni, Isaka Mitsuhiro, Kawabata Takanori, Imai Toru, Mori Keita, Muramatsu Koji, Hayashi Isamu, Kenmotsu Hirotsugu, Ohshima Keiichi, Urakami Kenichi, Nagashima Takeshi, Kusuhara Masatoshi, Akiyama Yasuto, Sugino Takashi, Ohde Yasuhisa, Yamaguchi Ken, Takahashi Toshiaki

Abstract excerpt

BACKGROUND: It is unclear whether clinical factors and immune microenvironment (IME) factors are associated with tumor mutation burden (TMB) in patients with nonsmall cell lung cancer (NSCLC). MATERIALS AND METHODS: We assessed TMB in surgical tumor specimens by performing whole exome sequencing. IME profiles, including PD-L1 tumor proportion score (TPS), stromal CD8 tumor-infiltrating lymphocyte (TIL) density,...

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PMID: 32400056
DOI: 10.1002/cam4.3107
PMCID: PMC7333844

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