Article
SNP array profiling of childhood adrenocortical tumors reveals distinct pathways of tumorigenesis and highlights candidate driver genes.
The Journal of clinical endocrinology and metabolism - 1 Jul 2012
Letouzé Eric, Rosati Roberto, Komechen Heloisa, Doghman Mabrouka, Marisa Laetitia, Flück Christa, de Krijger Ronald R, van Noesel Max M, Mas Jean-Christophe, Pianovski Mara A D, Zambetti Gerard P, Figueiredo Bonald C, Lalli Enzo
Abstract excerpt
CONTEXT: Childhood adrenocortical tumors (ACT) are rare malignancies, except in southern Brazil, where a higher incidence rate is associated to a high frequency of the founder R337H TP53 mutation. To date, copy number alterations in these tumors have only been analyzed by low-resolution comparative genomic hybridization. OBJECTIVE: We analyzed an international series of 25 childhood ACT using high-resolution...
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