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Article

Vitamin D receptor hypermethylation as a biomarker for pediatric adrenocortical tumors

15 Mar 2022

Abstract excerpt

Objective: Pediatric adrenocortical tumors (pACT) display complex genomic backgrounds, lacking robust prognostic markers and targeted therapeutic options. Vitamin D3 receptor (VDR) promoter hypermethylation and underexpression were reported in adrenocortical carcinomas from adult patients. In this study, we aimed to investigate VDR expression levels and methylation status in pACT and their clinical and prognostic...

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PMID: 35290212
DOI: 10.1530/eje-21-0879

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