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Article

A Novel System for Functional Determination of Variants of Uncertain Significance using Deep Convolutional Neural Networks.

Scientific reports - 6 Mar 2020

Zimmerman Lior, Zelichov Ori, Aizenmann Arie, Barbash Zohar, Vidne Michael, Tarcic Gabi

Abstract excerpt

Many drugs are developed for commonly occurring, well studied cancer drivers such as vemurafenib for BRAF V600E and erlotinib for EGFR exon 19 mutations. However, most tumors also harbor mutations which have an uncertain role in disease formation, commonly called Variants of Uncertain Significance (VUS), which are not studied or characterized and could play a significant role in drug resistance and relapse....

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PMID: 32144301
DOI: 10.1038/s41598-020-61173-1
PMCID: PMC7060242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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