Testing association of rare genetic variants with resistance to three common antiseizure medications.

doi:10.1111/epi.16467

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Article

Testing association of rare genetic variants with resistance to three common antiseizure medications.

Epilepsia - 1 Apr 2020

Wolking Stefan, Moreau Claudia, Nies Anne T, Schaeffeler Elke, McCormack Mark, Auce Pauls, Avbersek Andreja, Becker Felicitas, Krenn Martin, Møller Rikke S, Nikanorova Marina, Weber Yvonne G, Weckhuysen Sarah, Cavalleri Gianpiero L, Delanty Norman, Depondt Chantal, Johnson Michael R, Koeleman Bobby P C, Kunz Wolfram S, Marson Anthony G, Sander Josemir W, Sills Graeme J, Striano Pasquale, Zara Federico, Zimprich Fritz, Schwab Matthias, Krause Roland, Sisodiya Sanjay M, Cossette Patrick, Girard Simon L, Lerche Holger

Abstract excerpt

OBJECTIVE: Drug resistance is a major concern in the treatment of individuals with epilepsy. No genetic markers for resistance to individual antiseizure medication (ASM) have yet been identified. We aimed to identify the role of rare genetic variants in drug resistance for three common ASMs: levetiracetam (LEV), lamotrigine (LTG), and valproic acid (VPA). METHODS: A cohort of 1622 individuals of European descent...

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Identifiers

PMID: 32141622
DOI: 10.1111/epi.16467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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