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Article

Rare protein sequence variation in SV2A gene does not affect response to levetiracetam.

Epilepsy research - 1 Sept 2012

Dibbens Leanne M, Hodgson Bree L, Helbig Katherine L, Oliver Karen L, Mulley John C, Berkovic Samuel F, Scheffer Ingrid E

Abstract excerpt

Levetiracetam, a broad spectrum antiepileptic drug, binds to membrane protein SV2A. The protein coding region of SV2A was sequenced in 158 patients with focal or generalized epilepsies divided into three groups based on their response to levetiracetam: responders (>75% decrease), exacerbators (50...

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Identifiers

PMID: 22551666
DOI: 10.1016/j.eplepsyres.2012.04.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22551666-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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