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CRISPR/Cas9-Induced Loss of Keap1 Enhances Anti-oxidation in Rat Adipose-Derived Mesenchymal Stem Cells

18 Feb 2020

Abstract excerpt

Stem cells have become powerful tool in the treatment of many diseases due to their regenerative ability, and rapidly they promote development of regenerative medicine, such as traumatic brain injury. However, the high level of oxidant micro-environment in lesion region lead more than 99% cells into death. In this study, we used genetic methods to edit Keap1 gene in mesenchymal stem cells and observed their...

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Identifiers

PMID: 32132961
DOI: 10.3389/fneur.2019.01311

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