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ITGA5 induces mesenchymal transformation to promote gliomas progression via PI3K/AKT/mTORC1 signaling pathway

19 Apr 2025

Abstract excerpt

Glioma is a common malignant tumor of the central nervous system, characterized by high malignancy, strong invasiveness and high recurrence rate. Integrin α5 (ITGA5), a member of the integrin adhesion molecule family, has been reported to be associated with tumor progression and metastasis. In this study, we first identified the overexpression of ITGA5 in glioma through bioinformatics analysis. Kaplan-Meier...

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PMID: 40253517
DOI: 10.1038/s41598-025-98170-1

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