Puerarin 6″‐O‐xyloside suppresses growth, self‐renewal and invasion of lung cancer stem‐like cells derived from A549 cells via regulating Akt/c‐Myc signalling

Abstract excerpt

Cancer stem cells have been identified as the major cause of cancer initiation and progression. To investigate the effects of puerarin 6″-O-xyloside (PXY), derived from Pueraria lobata (Willd.) Ohwi, on lung cancer stem cells, we enriched and identified a subpopulation of lung cancer stem-like cells (LCSLCs) derived from lung adenocarcinoma A549 cells with traits including high self-renewal and invasive...

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