Article
A rat model of enhanced glycation mimics cardiac phenotypic components of human type 2 diabetes : A translational study using MRI.
Journal of diabetes and its complications - 1 May 2020
Castelhano Joao, Ribeiro Bruno, Sanches Mafalda, Graça Bruno, Saraiva Joana, Oliveiros Bárbara, Neves Christian, Rodrigues Tiago, Sereno José, Gonçalves Sónia, Ferreira Maria João, Seiça Raquel, Matafome Paulo, Castelo-Branco Miguel
Abstract excerpt
BACKGROUND: The success of translational research depends on how well animal models mimic the pathophysiology of the human phenotype, and on the identification of disease mechanisms such as enhanced glycation. METHODS: Here, we studied cardiac MRI and metabolic phenotypes in human type 2 diabetes (N = 106; 55 patients+51 controls) and animal models with distinct levels of fat diet and end glycation products, to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.