Article
A Prospective Italian Study on Baseline NS3 and NS5A Resistance to Direct-Acting Antivirals in a Real-World Setting of HIV-1/HCV Coinfected Patients and Association with Treatment Outcome.
Viruses - 28 Feb 2020
Bagaglio Sabrina, Hasson Hamid, Peano Luca, Vercesi Riccardo, Messina Emanuela, Galli Andrea, Foppa Caterina Uberti, Morsica Giulia
Abstract excerpt
We prospectively evaluated the frequency of natural resistance-associated substitutions (RASs) in the NS3 and NS5A regions according to different HCV genotypes and their possible effect on treatment outcome in HIV-1/HCV patients treated with direct-acting antivirals (DAAs). Baseline RASs in the NS3 and NS5A domains were investigated in 62 HIV-1/HCV patients treated with DAAs: 23 patients harbored HCV-GT1a, 26...
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