Article
Utility of public knowledge bases for the interpretation of comprehensive tumor molecular profiling results.
Clinical and experimental medicine - 1 Oct 2023
Lebedeva Alexandra, Timokhin Grigory, Ignatova Ekaterina, Kavun Alexandra, Veselovsky Egor, Sharova Margarita, Mileyko Vladislav, Yakushina Valentina, Kuznetsova Olesya, Stepanova Maria, Shilo Polina, Moiseenko Fedor, Volkov Nikita, Plaksa Igor, Isaev Andrey, Gayryan Margarita, Artemyeva Elizaveta, Zhabina Albina, Kramchaninov Mikhail, Shamrikova Valentina, Pokataev Ilya, Rumyantsev Alexey, Ledin Evgeny, Tryakin Alexey, Fedyanin Mikhail, Ivanov Maxim
Abstract excerpt
With the growing use of comprehensive tumor molecular profiling (CTMP), the therapeutic landscape of cancer is rapidly evolving. NGS produces large amounts of genomic data requiring complex analysis and subsequent interpretation. We sought to determine the utility of publicly available knowledge bases (KB) for the interpretation of the cancer mutational profile in clinical practice. Analysis was performed across...
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