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Article

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

27 Feb 2020

Abstract excerpt

Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting...

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Share to Epigenetics and DNA Methylation
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PMID: 32109421
DOI: 10.1016/j.ajhg.2020.02.006

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