Gnpat does not play an essential role in systemic iron homeostasis in murine model.

doi:10.1111/jcmm.15068

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Article

Gnpat does not play an essential role in systemic iron homeostasis in murine model.

Journal of cellular and molecular medicine - 1 Apr 2020

An Peng, Wang Jiaming, Wang Hao, Jiang Li, Wang Jia, Min Junxia, Wang Fudi

Abstract excerpt

The GNPAT variant rs11558492 (p.D519G) was identified as a novel genetic factor that modifies the iron-overload phenotype in homozygous carriers of the HFE p.C282Y variant. However, the reported effects of the GNPAT p.D519G variant vary among study populations. Here, we investigated the role of GNPAT in iron metabolism using Gnpat-knockout (Gnpat-/- ), Gnpat/Hfe double-knockout (Gnpat-/- Hfe-/- or DKO) mice and...

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PMID: 32108988
DOI: 10.1111/jcmm.15068
PMCID: PMC7171407

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