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Article

Mild Iron Overload as Seen in Individuals Homozygous for the Alpha-1 Antitrypsin Pi*Z Variant Does Not Promote Liver Fibrogenesis in HFE Knockout Mice.

Cells - 9 Nov 2019

Guldiken Nurdan, Hamesch Karim, Schuller Shari Malan, Aly Mahmoud, Lindhauer Cecilia, Schneider Carolin V, Fromme Malin, Trautwein Christian, Strnad Pavel

Abstract excerpt

The presence of the homozygous 'Pi*Z' variant of alpha-1 antitrypsin (AAT) ('Pi*ZZ' genotype) predisposes to liver fibrosis development, but the role of iron metabolism in this process remains unknown. Therefore, we assessed iron metabolism and variants in the Homeostatic Iron Regulator gene (HFE) as the major cause of hereditary iron overload in a large cohort of Pi*ZZ subjects without liver comorbidities. The...

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Identifiers

PMID: 31717526
DOI: 10.3390/cells8111415
PMCID: PMC6912453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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