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Article

Novel insights into reproductive ageing and menopause from genomics

28 Nov 2022

Abstract excerpt

The post-reproductive phase or menopause in females is triggered by a physiological timer that depends on a threshold of follicle number in the ovary. Curiously, reproductive senescence appears to be decoupled from chronological age and is instead thought to be a function of physiological ageing. Ovarian ageing is associated with a decrease in oocyte developmental competence, attributed to a concomitant increase...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Reproductive Biology and Fertility

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PMID: 36478237
DOI: 10.1093/humrep/deac256

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