Article
Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species.
Oncogene - 1 Apr 2020
Kasiri Sahba, Chen Baozhi, Wilson Alexandra N, Reczek Annika, Mazambani Simbarashe, Gadhvi Jashkaran, Noel Evan, Marriam Ummay, Mino Barbara, Lu Wei, Girard Luc, Solis Luisa M, Luby-Phelps Katherine, Bishop Justin, Kim Jung-Whan, Kim James
Abstract excerpt
Activation of the Hedgehog (Hh) signaling pathway by mutations within its components drives the growth of several cancers. However, the role of Hh pathway activation in lung cancers has been controversial. Here, we demonstrate that the canonical Hh signaling pathway is activated in lung stroma by Hh ligands secreted from transformed lung epithelia. Genetic deletion of Shh, the primary Hh ligand expressed in the...
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