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Article

Hedgehog Signaling Modulates Glial Proteostasis and Lifespan.

Cell reports - 25 Feb 2020

Rallis Andrew, Navarro Juan A, Rass Mathias, Hu Amélie, Birman Serge, Schneuwly Stephan, Thérond Pascal P

Abstract excerpt

The conserved Hedgehog signaling pathway has well-established roles in development. However, its function during adulthood remains largely unknown. Here, we investigated whether the Hedgehog signaling pathway is active during adult life in Drosophila melanogaster, and we uncovered a protective function for Hedgehog signaling in coordinating correct proteostasis in glial cells. Adult-specific depletion of Hedgehog...

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PMID: 32101741
DOI: 10.1016/j.celrep.2020.02.006

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