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Article

Integrative Molecular Analysis of Patients With Advanced and Metastatic Cancer

20 Sept 2019

Abstract excerpt

PURPOSE We developed a precision medicine program for patients with advanced cancer using integrative whole-exome sequencing and transcriptome analysis. PATIENTS AND METHODS Five hundred fifteen patients with locally advanced/metastatic solid tumors were prospectively enrolled, and paired tumor/normal sequencing was performed. Seven hundred fifty-nine tumors from 515 patients were evaluated. RESULTS Most frequent...

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PMID: 31592503
DOI: 10.1200/po.19.00047

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