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Article

Congenital generalized lipodystrophy: significance of triglyceride biosynthetic pathways.

Trends in endocrinology and metabolism: TEM - 1 Jul 2003

Agarwal Anil K, Garg Abhimanyu

Abstract excerpt

Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by marked lack of body fat since birth, which results in striking muscular appearance. Patients develop extreme insulin resistance and its complications, such as diabetes, hyperlipidemia and fatty liver. Mutations in the BSCL2 (which encodes seipin, a protein of unknown function) and AGPAT2 (which encodes...

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Source

Identifiers

PMID: 12826327
DOI: 10.1016/s1043-2760(03)00078-x

Genes

AGPAT2
BSCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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