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Article

Oscillatory expression of Hes1 regulates cell proliferation and neuronal differentiation in the embryonic brain.

Development (Cambridge, England) - 26 Feb 2020

Ochi Shohei, Imaizumi Yui, Shimojo Hiromi, Miyachi Hitoshi, Kageyama Ryoichiro

Abstract excerpt

The expression of the transcriptional repressor Hes1 oscillates in many cell types, including neural progenitor cells (NPCs), but the significance of Hes1 oscillations in development is not fully understood. To examine the effect of altered oscillatory dynamics of Hes1, we generated two types of Hes1 knock-in mice, a shortened (type-1) and an elongated (type-2) Hes1 gene, and examined their phenotypes focusing on...

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Source

Identifiers

PMID: 32094111
DOI: 10.1242/dev.182204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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