Article
Hes1 is required for the development of craniofacial structures derived from ectomesenchymal neural crest cells.
The Journal of craniofacial surgery - 1 Sept 2010
Akimoto Minekatsu, Kameda Yoko, Arai Yuta, Miura Masaaki, Nishimaki Toshiyuki, Takeda Akira, Uchinuma Eiju
Abstract excerpt
The cranial neural crest cells contribute extensively to the formation of skeletogenic mesenchyme in the head and neck. Hes1 functions as a repressor of basic helix-loop-helix transcription factors and is implicated in controlling the maintenance of undifferentiated cells and the timing of cell differentiation. We show here that Hes1 homozygous null mutant mice exhibit multiple craniofacial malformations...
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