Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABAT and ALDH6A1, regulated by transcription factor HNF4A, suppress tumorigenic capability in clear cell renal cell carcinoma

24 Feb 2020

Abstract excerpt

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by metabolic reprogramming. ABAT and ALDH6A1 are metabolic enzymes. In this study, we aim to investigate the associations of ABAT and ALDH6A1 with the malignancy of ccRCC cells. METHODS: The gene expression levels of ABAT and ALDH6A1 in ccRCC were analyzed from gene expression microarray datasets and RNA sequencing data. Clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Enzymes and Metabolism
Share to Autophagy in Disease and Therapy
Share to Cancer, Hypoxia, and Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32093682
DOI: 10.1186/s12967-020-02268-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABAT and ALDH6A1, regulated by transcription factor HNF4A, suppress tumorigenic capability in clear cell renal cell carcinomaPMID 32093682Read ↗

Expression of AOX1 Predicts Prognosis of Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

ACAT1 and Metabolism-Related Pathways Are Essential for the Progression of Clear Cell Renal Cell Carcinoma (ccRCC), as Determined by Co-expression Network AnalysisSemantic proximity Read ↗

Redox Metabolism‐Associated Molecular Classification of Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

Glycolysis‐Related Genes Serve as Potential Prognostic Biomarkers in Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

Functional deficiency of succinate dehydrogenase promotes tumorigenesis and development of clear cell renal cell carcinoma through weakening of ferroptosisSemantic proximity Read ↗

SDHB Suppresses the Tumorigenesis and Development of ccRCC by Inhibiting GlycolysisSemantic proximity Read ↗

Genetic and metabolic hallmarks of clear cell renal cell carcinoma.Semantic proximity Read ↗

miR-1182-mediated ALDH3A2 inhibition affects lipid metabolism and progression in ccRCC by activating the PI3K-AKT pathwaySemantic proximity Read ↗

VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2Semantic proximity Read ↗

Functional succinate dehydrogenase deficiency and loss of ascorbic acid transporter SLC23A1 are pathognomonic adverse features of clear cell renal cancerSemantic proximity Read ↗

Role of Metabolic Reprogramming of Long non-coding RNA in Clear Cell Renal Cell CarcinomaSemantic proximity Read ↗

Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.