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Article

Driver Mutation Analysis and PD-L1 Expression in Synchronous Double Primary Lung Cancer.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Apr 2018

Jia Xiaoli, Zhang Liping, Wu Wei, Zhang Wei, Wu Chunyan

Abstract excerpt

Synchronous double primary lung cancer (SDPLC) is detected more frequently than in the past. However, the genetic features, diagnosis, and outcome are not well known. For diagnostic and management applications, we collected 110 lesions from 55 patients who underwent surgical resection to analyze the 5 known driver mutations (EGFR, KRAS, BRAF, EML4-ALK, and ROS1) and programmed cell death ligand 1 (PD-L1)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms, Multiple Primary

Share to Oncogene Proteins, Fusion

Share to Protein-Tyrosine Kinases

Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 27438512
DOI: 10.1097/PAI.0000000000000412

Genes

ALK
EGFR
EML4
KRAS
BRAF
ROS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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