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Article

Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors.

Bioorganic & medicinal chemistry letters - 1 Oct 2011

Zeng Hongbo, Belanger David B, Curran Patrick J, Shipps Gerald W, Miao Hua, Bracken Jack B, Arshad Siddiqui M, Malkowski Michael, Wang Yan

Abstract excerpt

A series of substituted imidazo[1,2-a]pyrazin-8-amines were discovered as novel breast tumor kinase (Brk)/protein tyrosine kinase 6 (PTK6) inhibitors. Tool compounds with low-nanomolar Brk inhibition activity, high selectivity towards other kinases and desirable DMPK properties were achieved to enable the exploration of Brk as an oncology target.

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Source

Identifiers

PMID: 21855335
DOI: 10.1016/j.bmcl.2011.07.101

Genes

PTK6
DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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