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Article

AIDS/HIV. HIV interplay with SAMHD1.

Science (New York, N.Y.) - 16 Mar 2012

Schaller Torsten, Goujon Caroline, Malim Michael H

Abstract excerpt

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Topics

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Share to Adaptive Immunity
Share to Autoimmune Diseases of the Nervous System
Share to HIV-2
Share to Monomeric GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nervous System Malformations

Share to SAM Domain and HD Domain-Containing Protein 1

Share to Simian Immunodeficiency Virus

Share to Viral Regulatory and Accessory Proteins

Source

Identifiers

PMID: 22422971
DOI: 10.1126/science.1221057

Genes

SAMHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AIDS/HIV. HIV interplay with SAMHD1.PMID 22422971Read ↗

SAMHD1 restricts HIV-1 infection in resting CD4+ T cellsSemantic proximity Read ↗

CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levelsSemantic proximity Read ↗

The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral ResponseSemantic proximity Read ↗

How Samhd1 changes our view of viral restrictionSemantic proximity Read ↗

SAMHD1’s protein expression profile in humansSemantic proximity Read ↗

Evolutionary and Functional Analyses of the Interaction between the Myeloid Restriction Factor SAMHD1 and the Lentiviral Vpx ProteinSemantic proximity Read ↗

A Virus-Packageable CRISPR System Identifies Host Dependency Factors Across Multiple HIV-1 StrainsSemantic proximity Read ↗

Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1Semantic proximity Read ↗

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV InfectionSemantic proximity Read ↗

The Ability of Primate Lentiviruses to Degrade the Monocyte Restriction Factor SAMHD1 Preceded the Birth of the Viral Accessory Protein VpxSemantic proximity Read ↗

Tight Interplay among SAMHD1 Protein Level, Cellular dNTP Levels, and HIV-1 Proviral DNA Synthesis Kinetics in Human Primary Monocyte-derived MacrophagesSemantic proximity Read ↗

SAMHD1: a new contributor to HIV-1 restriction in resting CD4+T-cellsSemantic proximity Read ↗

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