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Article

Loss of endothelin type B receptor function improves insulin sensitivity in rats.

Canadian journal of physiology and pharmacology - 1 Sept 2020

Rivera-Gonzalez Osvaldo J, Kasztan Malgorzata, Johnston Jermaine G, Hyndman Kelly A, Speed Joshua S

Abstract excerpt

High salt intake (HS) is associated with obesity and insulin resistance. ET-1, a peptide released in response to HS, inhibits the actions of insulin on cultured adipocytes through ET-1 type B (ETB) receptors; however, the in vivo implications of ETB receptor activation on lipid metabolism and insulin resistance is unknown. We hypothesized that activation of ETB receptors in response to HS intake promotes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32083942
DOI: 10.1139/cjpp-2019-0666
PMCID: PMC7442597

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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