Article
Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants.
Nature communications - 19 Feb 2020
Donovan Margaret K R, D'Antonio-Chronowska Agnieszka, D'Antonio Matteo, Frazer Kelly A
Abstract excerpt
The Genotype-Tissue Expression (GTEx) resource has provided insights into the regulatory impact of genetic variation on gene expression across human tissues; however, thus far has not considered how variation acts at the resolution of the different cell types. Here, using gene expression signatures obtained from mouse cell types, we deconvolute bulk RNA-seq samples from 28 GTEx tissues to quantify cellular...
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