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Article

Microcystin-LR ameliorates pulmonary fibrosis via modulating CD206+ M2-like macrophage polarization.

Cell death & disease - 19 Feb 2020

Wang Jie, Xu Lizhi, Xiang Zou, Ren Yan, Zheng Xiufen, Zhao Qingya, Zhou Qunzhi, Zhou Yuefen, Xu Lin, Wang Yaping

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a group of chronic interstitial pulmonary diseases characterized by myofibroblast proliferation and extracellular matrix deposition with limited treatment options. Based on our previous observation, we hypothesized microcystin-leucine arginine (LR), an environmental cyanobacterial toxin, could potentially suppress pulmonary fibrosis. In this study, we first demonstrated that...

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Identifiers

PMID: 32075954
DOI: 10.1038/s41419-020-2329-z
PMCID: PMC7031231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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