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Article

Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels.

Aquatic toxicology (Amsterdam, Netherlands) - 1 Jun 2018

Chen Yabing, Wang Jing, Chen Xiang, Li Dongmei, Han Xiaodong

Abstract excerpt

Microcystin-leucine arginine (MC-LR) causes decline of serum testosterone levels resulting in impaired spermatogenesis; however, the underlying molecular mechanisms are not fully understood. In this study, we aimed to investigate the effects of MC-LR exposure on the number of Leydig cells (LCs) in testis. Following chronic low dose exposure to MC-LR, the number of LCs was markedly decreased while macrophages were...

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Identifiers

PMID: 29621671
DOI: 10.1016/j.aquatox.2018.03.018

Genes

TNF
GAS6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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