Article
Propionic Acid Promotes the Virulent Phenotype of Crohn's Disease-Associated Adherent-Invasive Escherichia coli.
Cell reports - 18 Feb 2020
Ormsby Michael J, Johnson Síle A, Carpena Nuria, Meikle Lynsey M, Goldstone Robert J, McIntosh Anne, Wessel Hannah M, Hulme Heather E, McConnachie Ceilidh C, Connolly James P R, Roe Andrew J, Hasson Conor, Boyd Joseph, Fitzgerald Eamonn, Gerasimidis Konstantinos, Morrison Douglas, Hold Georgina L, Hansen Richard, Walker Daniel, Smith David G E, Wall Daniel M
Abstract excerpt
Propionic acid (PA) is a bacterium-derived intestinal antimicrobial and immune modulator used widely in food production and agriculture. Passage of Crohn's disease-associated adherent-invasive Escherichia coli (AIEC) through a murine model, in which intestinal PA levels are increased to mimic the human intestine, leads to the recovery of AIEC with significantly increased virulence. Similar phenotypic changes are...
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