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Phage intervention improves colitis and response to corticosteroids by attenuating virulence of Crohn’s disease–associated bacteria

8 Jul 2026

Abstract excerpt

Abstract Adherent-invasive Escherichia coli (AIEC) exhibit proinflammatory properties and have been implicated in the pathogenesis of Crohn’s disease (CD), a form of inflammatory bowel disease (IBD). Antibiotic use in CD lacks specificity and may worsen microbiome disruption, prompting interest in bacteriophages (phages) for targeted microbiome editing. Here, we identified HER259, a phage active against the...

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PMID: 42418560
DOI: 10.1126/scitranslmed.adz4589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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