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Article

SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness

18 Feb 2020

Abstract excerpt

Metastasis is the leading cause of breast cancer-related death and poses a substantial clinical burden owing to a paucity of targeted treatment options. The clinical manifestations of metastasis occur years-to-decades after initial diagnosis and treatment because disseminated tumor cells readily evade detection and resist therapy, ultimately giving rise to recurrent disease. Using an unbiased genetic screen, we...

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PMID: 32071280
DOI: 10.26508/lsa.201900427

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