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Article

Identification of molecular determinants of primary and metastatic tumour re-initiation in breast cancer.

Nature cell biology - 1 May 2015

Ross Jason B, Huh Doowon, Noble Lisa B, Tavazoie Sohail F

Abstract excerpt

Through in vivo selection of multiple ER-negative human breast cancer populations for enhanced tumour-forming capacity, we have derived subpopulations that generate tumours more efficiently than their parental populations at low cell numbers. Tumorigenic-enriched subpopulations exhibited increased expression of LAMA4, FOXQ1 and NAP1L3—genes that are also expressed at greater levels by independently derived...

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Identifiers

PMID: 25866923
DOI: 10.1038/ncb3148
PMCID: PMC4609531

Genes

LAMA4
FOXQ1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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