Article
Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance.
AIDS (London, England) - 23 Apr 2008
Liu Lin, May Susanne, Richman Douglas D, Hecht Frederick M, Markowitz Martin, Daar Eric S, Routy Jean-Pierre, Margolick Joseph B, Collier Ann C, Woelk Christopher H, Little Susan J, Smith Davey M
Abstract excerpt
OBJECTIVE: We compared eight genotypic interpretation methods to determine whether the method used would affect the rates of reported transmitted drug resistance. DESIGN: Retrospective cohort study. METHODS: For the International AIDS Society-USA method we classified a mutation as resistant if it was a 'major' resistance-associated mutation. For the Stanford algorithm, we classified a mutation as resistant if the...
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