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Article

Effect of Copper on the Mitochondrial Carnitine/Acylcarnitine Carrier Via Interaction with Cys136 and Cys155. Possible Implications in Pathophysiology.

Molecules (Basel, Switzerland) - 13 Feb 2020

Giangregorio Nicola, Tonazzi Annamaria, Console Lara, Prejanò Mario, Marino Tiziana, Russo Nino, Indiveri Cesare

Abstract excerpt

The effect of copper on the mitochondrial carnitine/acylcarnitine carrier (CAC) was studied. Transport function was assayed as [3H]carnitine/carnitine antiport in proteoliposomes reconstituted with the native protein extracted from rat liver mitochondria or with the recombinant CAC over-expressed in E. coli. Cu2+ (as well as Cu+) strongly inhibited the native transporter. The inhibition was reversed by GSH...

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PMID: 32070004
DOI: 10.3390/molecules25040820
PMCID: PMC7070283

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