Article
Multi-walled carbon nanotubes exacerbate doxorubicin-induced cardiotoxicity by altering gut microbiota and pulmonary and colonic macrophage phenotype in mice.
Toxicology - 15 Apr 2020
Liu Xiaoxiao, Liu Yanzhuo, Chen Xuewei, Wang Chenlong, Chen Xuehan, Liu Wen, Huang Keqing, Chen Honglei, Yang Jing
Abstract excerpt
Epidemiologic studies show that the levels of air pollutants and particulate matter are positively associated with the morbidity and mortality of cardiovascular diseases. Here we demonstrate that the intratracheal instillation of multi-walled carbon nanotubes (MWCNTs), a standard fine particle, exacerbate doxorubicin (DOX)-induced cardiotoxicity in mice through altering gut microbiota and pulmonary and colonic...
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