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Article

The effect of m2 peptide targeted nanoliposomes containing crocin on induction of phenotypic change in tumor macrophages to M1 state.

Life sciences - 1 Oct 2023

Abdi Hakimeh, Arabi Leila, Montazer Mehdi, Askarizadeh Anis, Zamani Parvin, Hosseinzadeh Hossein, Jaafari Mahmoud Reza, Mosaffa Fatemeh

Abstract excerpt

AIMS: Crocin has immunomodulatory and anticancer effects. In this study, crocin was used to induce the M1 phenotype in mouse tumor macrophages. MAIN METHODS: A targeted liposomal formulation with m2 peptide was prepared and characterized to deliver crocin to the M2 macrophages present in the tumor environment. RT-qPCR and IHC were performed for in vitro and in vivo (in C26 colon carcinoma mouse model at a dose of...

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Identifiers

PMID: 37524160
DOI: 10.1016/j.lfs.2023.121992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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