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Article

MicroRNA-4516-mediated regulation of MAPK10 relies on 3' UTR cis-acting variants and contributes to the altered risk of Hirschsprung disease.

Journal of medical genetics - 1 Sept 2020

Wang Yang, Jiang Qian, Chakravarti Aravinda, Cai Hao, Xu Ze, Wu Wenjie, Gu Beilin, Li Long, Cai Wei

Abstract excerpt

BACKGROUND: Hirschsprung disease (HSCR) is a life-threatening congenital disorder in which the enteric nervous system is completely missing from the distal gut. Recent studies have shown that miR-4516 markedly inhibits cell migration, and as one of its potential targets, MAPK10 functions as a modifier for developing HSCR. We thus aimed to evaluate the role of miR-4516 and MAPK10 in HSCR and how they contribute to...

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Identifiers

PMID: 32066630
DOI: 10.1136/jmedgenet-2019-106615
PMCID: PMC7877481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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