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Article

Cumulative Risk Impact of RET, SEMA3, and NRG1 Polymorphisms Associated With Hirschsprung Disease in Han Chinese.

Journal of pediatric gastroenterology and nutrition - 1 Mar 2017

Li Qi, Zhang Zhen, Diao Mei, Gan Liang, Cheng Wei, Xiao Ping, Su Lin, Shangguan Shaofang, Jiang Qian, Li Long

Abstract excerpt

OBJECTIVES: Hirschsprung disease (HSCR) is a congenital aganglionosis of myenteric and submucosal plexuses affecting a variable length of the intestine. The incidence of HSCR is approximately 1 of 5000 live births; however, the risk shows remarkable individual variation caused by single nucleotide polymorphisms (SNPs) at the RET, SEMA3, and NRG1 loci. The present study investigated the effects of these variants...

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Source

Identifiers

PMID: 27203398
DOI: 10.1097/MPG.0000000000001263

Genes

RET
NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Cumulative Risk Impact of RET, SEMA3, and NRG1 Polymorphisms Associated With Hirschsprung Disease in Han Chinese.PMID 27203398Read ↗

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