Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common genetic variants in GAL, GAP43 and NRSN1 and interaction networks confer susceptibility to Hirschsprung disease.

Journal of cellular and molecular medicine - 1 Jul 2018

Wang Yang, Yan Weihui, Wang Jun, Zhou Ying, Chen Jie, Gu Beilin, Cai Wei

Abstract excerpt

Hirschsprung disease (HSCR) is a severe multifactorial genetic disorder. Microarray studies indicated GAL, GAP43 and NRSN1 might contribute to the altered risk in HSCR. Thus, we focused on genetic variations in GAL, GAP43 and NRSN1, and the gene-gene interactions involved in HSCR susceptibility. We recruited a strategy combining case-control study and MassArray system with interaction network analysis. For GAL,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules, Neuronal
Share to Extracellular Matrix Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Galanin

Share to Hirschsprung Disease

Share to Patched-1 Receptor

Share to Receptors, GABA-A

Share to Reelin Protein

Share to Serine Endopeptidases

Source

Open in PubMed Open full text

Identifiers

PMID: 29654647
DOI: 10.1111/jcmm.13612
PMCID: PMC6010875

Genes

GAL
GAP43
NRSN1
GABRG2
PTCH1
RELN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common genetic variants in GAL, GAP43 and NRSN1 and interaction networks confer susceptibility to Hirschsprung disease.PMID 29654647Read ↗

Contribution of Common Variants in GABRG2, RELN and NRG3 and Interaction Networks to the Risk of Hirschsprung Disease.Semantic proximity Read ↗

Genetic variants in RET, ARHGEF3 and CTNNAL1, and relevant interaction networks, contribute to the risk of Hirschsprung disease.Semantic proximity Read ↗

Cumulative Risk Impact of RET, SEMA3, and NRG1 Polymorphisms Associated With Hirschsprung Disease in Han Chinese.Semantic proximity Read ↗

Mutations in the NRG1 gene are associated with Hirschsprung disease.Semantic proximity Read ↗

Sporadic Hirschsprung Disease: Mutational Spectrum and Novel Candidate Genes Revealed by Next-generation Sequencing.Semantic proximity Read ↗

NRG1 variant effects in patients with Hirschsprung disease.Semantic proximity Read ↗

The Emerging Genetic Landscape of Hirschsprung Disease and Its Potential Clinical ApplicationsSemantic proximity Read ↗

The single nucleotide polymorphisms in Smad-interacting protein 1 gene contribute to its ectopic expression and susceptibility in Hirschsprung's disease.Semantic proximity Read ↗

Common variants of NRG1 and ITGB4 confer risk of Hirschsprung disease in Han Chinese population.Semantic proximity Read ↗

Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease.Semantic proximity Read ↗

Fine mapping of the NRG1 Hirschsprung's disease locus.Semantic proximity Read ↗

Identification of Genes Associated With Hirschsprung Disease, Based on Whole-Genome Sequence Analysis, and Potential Effects on Enteric Nervous System Development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.