Article
A common polymorphism in pre-miR-146a underlies Hirschsprung disease risk in Han Chinese.
Experimental and molecular pathology - 1 Dec 2014
Zhu Hairong, Cai Peng, Zhu Dongmei, Xu Chao, Li Hongxing, Tang Junwei, Xie Hua, Qin Yufeng, Sharan Ankur, Tang Weibing, Xia Yankai
Abstract excerpt
BACKGROUND: Hirschsprung disease (HSCR) is a rare multigenic congenital disorder characterized by the absence of the enteric ganglia. To date, single nucleotide polymorphisms (SNPs) in pre-miRNAs have been confirmed related with some diseases. Thus, we hypothesized that pre-miRNA polymorphisms might contribute to HSCR susceptibility. We investigated whether rs2910164 and rs11614913 of pre-miR-146a and...
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