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Platelet mitochondrial DNA methylation predicts future cardiovascular outcome in adults with overweight and obesity

17 Feb 2020

Abstract excerpt

BACKGROUND: The association between obesity and cardiovascular disease (CVD) is proven, but why some adults with obesity develop CVD while others remain disease-free is poorly understood. Here, we investigated whether mitochondrial DNA (mtDNA) methylation in platelets is altered prior to CVD development in a population of adults with overweight and obesity. METHODS: We devised a nested case-control study of 200...

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PMID: 32066501
DOI: 10.1186/s13148-020-00825-5

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