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Article

A comprehensive contribution of genetic variations of the insulin-like growth factor 1 signalling pathway to stroke susceptibility.

Atherosclerosis - 1 Mar 2020

Yao Yingshui, Zhu Hui, Zhu Lijun, Fang Zhengmei, Fan Yao, Liu Chunlan, Tian Yuanrui, Chen Yan, Tang Wuzhuang, Ren Zhanyun, Li Jie, Yang Song, Chen Yanchun, Zhao Xianghai, Shen Chong

Abstract excerpt

BACKGROUND AND AIMS: The insulin-like growth factor (IGF)-1 signalling pathway has been implicated in the pathogenesis of atherosclerosis; however, the mechanism underlying its role in stroke remains unexplained. Herein, we aimed to explore the effects of genetic polymorphisms in the IGF1 pathway on stroke in the Chinese Han population. METHODS: Twenty-six single-nucleotide polymorphisms (SNPs) in IGF1 pathway...

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PMID: 32065979
DOI: 10.1016/j.atherosclerosis.2020.01.009

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