Article
Genetic variation at the IGF1 locus shows association with post-stroke outcome and to circulating IGF1.
European journal of endocrinology - 1 Dec 2013
Aberg N David, Olsson Sandra, Aberg Daniel, Jood Katarina, Stanne Tara M, Nilsson Michael, Blomstrand Christian, Svensson Johan, Isgaard Jörgen, Jern Christina
Abstract excerpt
OBJECTIVE: In humans, serum IGF1 (s-IGF1) is associated with outcome after ischemic stroke (IS). Therefore variation at the IGF1 locus could also associate with both IS and s-IGF1. We investigated whether genetic variation at the IGF1 locus is associated with i) s-IGF1, ii) IS occurrence, iii) IS severity, and iv) post-stroke outcome. DESIGN/METHODS: Patients (n=844; 66% males, mean age 56 years) and community...
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