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Extracellular matrix guidance of autophagy: a mechanism regulating cancer growth

1 Jan 2022

Abstract excerpt

The extracellular matrix (ECM) exists as a dynamic network of biophysical and biochemical factors that maintain tissue homeostasis. Given its sensitivity to changes in the intra- and extracellular space, the plasticity of the ECM can be pathological in driving disease through aberrant matrix remodelling. In particular, cancer uses the matrix for its proliferation, angiogenesis, cellular reprogramming and...

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PMID: 34982945
DOI: 10.1098/rsob.210304

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