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Article

Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase.

Human molecular genetics - 1 Sept 2004

Leary Scot C, Kaufman Brett A, Pellecchia Giovanna, Guercin Guy-Hellen, Mattman Andre, Jaksch Michaela, Shoubridge Eric A

Abstract excerpt

Human SCO1 and SCO2 are paralogous genes that code for metallochaperone proteins with essential, but poorly understood, roles in copper delivery to cytochrome c oxidase (COX). Mutations in these genes produce tissue-specific COX deficiencies associated with distinct clinical phenotypes, although both are ubiquitously expressed. To investigate the molecular function of the SCO proteins, we characterized the...

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Source

Identifiers

PMID: 15229189
DOI: 10.1093/hmg/ddh197

Genes

SCO1
SCO2
COX17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase.PMID 15229189Read ↗

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