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Article

Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes.

Journal of affective disorders - 1 Mar 2020

Ahmed Ahmed T, MahmoudianDehkordi Siamak, Bhattacharyya Sudeepa, Arnold Matthias, Liu Duan, Neavin Drew, Moseley M Arthur, Thompson J Will, Williams Lisa St John, Louie Gregory, Skime Michelle K, Wang Liewei, Riva-Posse Patricio, McDonald William M, Bobo William V, Craighead W Edward, Krishnan Ranga, Weinshilboum Richard M, Dunlop Boadie W, Millington David S, Rush A John, Frye Mark A, Kaddurah-Daouk Rima

Abstract excerpt

BACKGROUND: Acylcarnitines have important functions in mitochondrial energetics and β-oxidation, and have been implicated to play a significant role in metabolic functions of the brain. This retrospective study examined whether plasma acylcarnitine profiles can help biochemically distinguish the three phenotypic subtypes of major depressive disorder (MDD): core depression (CD+), anxious depression (ANX+), and...

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Identifiers

PMID: 32056779
DOI: 10.1016/j.jad.2019.11.122
PMCID: PMC7024064

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